Endocrine Abstracts

Introduction: The prevalence of obesity is still increasing and is accompanied by significant health problems. High exposure to glucocorticoids, including the stress hormone cortisol, has been suggested to play a role in the development of obesity and associated cardiometabolic derangements. We previously showed that obese persons are exposed to high long-term cortisol levels as measured in scalp hair. It is not known whether these elevated cortisol levels decrease with weight...

IntroductionAltered levels of hormonal appetite regulators have been observed in obesity (BMI ≥ 30.0 kg/m2), most prominently increases of insulin and leptin (indicating resistance) as well as decreases of adiponectin–all of which are long-term energy regulators and adiposity signals. Disrupted signaling of these hormones may have detrimental effects on metabolism, but may also promote weight gain. Weight loss is often accompanied ...

Background: Obesity (BMI ≤ 30 kg/m2) is a chronic and relapsing disease, associated with numerous co-morbidities. Lifestyle intervention is the cornerstone of treatment of obesity, and is considered effective when weight loss of ≤ 5% is achieved. Here, we describe changes in physiological, psychological and behavioral health outcomes in response to a multidisciplinary combined lifestyle intervention (CLI).MethodsIn this longitudinal study we evaluated 97...

BackgroundLong-term glucocorticoids, as measured in scalp hair (HairGC), are associated with obesity and the metabolic syndrome (MetS). It is not known whether this represents a state of obesity or whether chronic hypercortisolism may influence the course or reversibility of obesity. In this study we longitudinally examine the relation between HairGC concentrations and metabolic syndrome parameters in patients with obesity who participate in a 1.5 year i...